What’s the right dose of CBD when you take it orally? It’s a simple question with a muddled answer.
One complicating factor is your most recent meal. Research has shown that only about 3-10% of CBD is absorbed into the bloodstream when taken on an empty stomach, but you may get up to five times as much if you first eat a fatty meal. Scientists at GW Research, which develops pharmaceutical cannabis extracts such as Epidiolex, recently organized a rather strange study to further assess this phenomenon.
They studied CBD absorption after five different meal conditions — 10 hours fasting, light breakfast, heavy breakfast, a tall glass of milk, and alcohol in lemonade. Participants also received a large dose of CBD, 750 mg. The results for the light and heavy breakfasts were consistent with previous data.
Taking CBD right after guzzling half a liter of milk also increased CBD absorption, but not to the same degree. Just under half of the subjects experienced minor adverse effects (like headache, tiredness, nausea) at this large 750 mg dose of CBD.
The fifth and final condition, taking CBD with alcohol, is hard to grasp. Participants took their 750 mg dose of CBD, then were required to drink 40 grams of alcohol — tantamount to five standard drinks — within five minutes. These participants hadn’t eaten in at least ten hours, having forgone breakfast for the experiment.